A breakthrough patent awarded to a New Jersey Institute of Technology (NJIT) researcher will enable manufacturers to create a device to detect miniscule amounts of airborne pollutants. Using computer chip technology, Somenath Mitra, PhD, professor and chair of NJIT’s Department of Chemistry and Environmental Sciences, has developed …

Scientists of the University of Twente (The Netherlands) succeed in speeding up the fluid flow in a micro channel using tiny and rapidly imploding gas bubbles that also provide a new way of mixing fluids within a lab-on-a-chip, without the need of complicated external components. The scientists led by Dr. …

Shortly after I posted “Proteomics made faster” I saw another research article published on the topic. Now, Detlev Belder and colleagues at the University of Regensburg, have developed a glass microchip that directly couples electrophoretic separation techniques with the electrospray process. As per “Chemistry World“:
Chemists in …

The large-scale studies of structure and function of proteins (proteomics) are performed using a variety of analytical techniques from two-dimensional gel electrophoresis, immunoaffinity chromatography to tandem and MALDI-TOF mass spectrometry. The words “large-scale” in proteomics definition refers to the fact that the number of proteins that …

Almost two weeks ago there was a question regarding Nano HPLC technology that I attempted to answer and in that post I mentioned Agilent as one of the pioneers in the Nano LC field. Agilent’s “nano” workhorse is a 1200 Series HPLC-Chip/MS system, which …

The HPLC method used a C8 column and the potassium chloride in aqueous acetic acid as a mobile phase with a linear gradient. The retention time was a bit over 20 min and the identity of the peak was confirmed as furosine by MS (mass spectrometry).

Nano HPLC is a relatively new development in chromatography world driven by recent advancements in proteomics that would require decreasing of inner diameter (ID) of liquid chromatography (LC) column to allow for a smaller sample amount and to increase sensitivity.